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Genres: comedy, tournament
Themes: Sports
Age Rating: PG-13 - Teens 13 or older

Plot Summary: Kobayakawa Sena is a little guy who always get picked on by the bullies in school. Since elementary school, he always play the role of the ‘errand boy’ to the extent that he has become swift and fast in his movements. Coincidentally, Hiruma Youichi and Kurita Ryukan are looking for a fast running back for their American Football team (Amefuto) and want to put Sena in the team. To hide their new ’star’ player from the eyes of other High Schools, Hiruma encases Sena in a Amefuto helmet with a dark visor and name him Eyeshield #21. (Source: ANN)

Episodes: 145
Status: Finished Airing
Aired: Apr 6, 2005 to Mar 19, 2008

Opening Theme:
#1: “Break Through” by Coming Century [eps 01-35]
#2: “Innocence” by 20th Century [ep 36- 64]
#3: “Dang Dang” by ZZ
#4: “BLAZE LINE” by BACK-ON
#5: “Hanno no Runningback” by SHORT LEG SUMMER (eps 127-)

Ending Theme:
#1: “Be Free” by Rikkenzu [eps 01-13]
#2: “Blaze Away” by The Trax [eps 14-35]
#3: “Goal” by Beni Arashiro [ep 36- 64]
#4: “Run to Win!” by Aya Hirano, Miyu Irino, Koichi Nagano, Kappei Yamaguchi
#6: “Flower” by BACK-ON (eps 117-126)
#7: “Song of Power” by SHORT LEG SUMMER (eps 127-)
#8: “Innocence” by 20th Century [ep 145]